Cavo et al. (2012) conducted a randomized, phase 3 study of stem cell transplantation (SCT), in which a sample of 161 myeloma patients received consolidation therapy three months after SCT. Complete response (CR) was measured before and after consolidation. An increase in CR following consolidation was observed. Given the following observed frequencies, you need to test the claim that the proportion of patients with CR before consolidation is the same as the proportion of patients with CR after consolidation at the 0.05 significance level. What is the value of the appropriate test statistic?