1. For the following set of compounds: show if they are drug-like or not (as applied to orally bioavailable drugs), use different measures. (24%)


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4                                                                                                                    5








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2. Are the compounds likely to penetrate the brain?  Use different measures to estimate this. (24%)



3. You are a CEO of a pharmaceutical company; produce a set of rules for your discovery scientists to reduce the attrition rates of your candidate drugs.  (52%)

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