1-Restate your PICOT question and its significance to nursing practice.
Here is the Picot question:
In older adult patients receiving antibiotic therapy, is the administration of probiotic effective in comparison with patient not receiving probiotic in preventing Clostridium difficile associated diarrhea over a period of eight weeks post antibiotic therapy?
2-Summarize the findings from the articles you selected for your literature review. Describe at least one nursing practice that is supported by the evidence in the articles. Justify your response with specific references to at least 2 of the articles.
3-Explain how the evidence-based practice that you identified contributes to better outcomes. In addition, identify potential negative outcomes that could result from failing to use the evidence-based practice.
4-Outline the strategy for disseminating the evidence-based practice that you identified throughout your practice setting. Explain how you would communicate the importance of the practice to your colleagues. Describe how you would move from disseminating the information to implementing the evidence-based practice within your organization. How would you address concerns and opposition to the change in practice?
Article selected for the literature review:
Johnston, B., Ma, S., Goldenberg, L., Thorlund, K., Vandvik, P., Loeb, M., & Guyatt, G. (2012). Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Annals Of Internal Medicine, 157(12), 878-888.
Avadhani, A., & Miley, H. (2011). Probiotics prevention of antibiotic-associated diarrhea and Clostridium difficile-associated disease in hospitalized adult. A meta-analysis. Journal Of The American Academy Of Nurse Practitioners. 23(6), 269-274. doi:10.1111.1745-7599.2011.00617.x
Allen, S. J., Wareham, K., Wang, D., Bradley, C., Hutchings, H., Harris, W., & Mack D. (2013). Lactobacilli and Bifidobacteria in the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea in older inpatients (PLACIDE): a randomized, double blind, placebo-controlled, multicenter trial. Lancet, 382(9900), 1249-1257. doi:10.106/S0140-6736(13)61218-0
Polit, D. F., & Beck, C. T. (2012). Nursing research: Generating and assessing evidence for nursing practice (Laureate Education, Inc., custom ed.). Philadelphia, PA: Lippincott Williams & Wilkins.